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By contrast, IR group revealed pronounced pathological changes, including marked myofiber degeneration, cytoplasmic vacuolization, interstitial edema, dense neutrophil infiltration, and prominent vascular congestion, consistent with severe ischemia–reperfusion injury

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Managing Side Effects in Research Settings Strategies that have proven effective in clinical trials for managing cagrilintide-related side effects include: ✅ Slower titration schedules – Extending time between dose increases ✅ Meal timing adjustments – Taking doses after meals rather than before ✅ Hydration optimization – Maintaining adequate fluid intake ✅ Dietary modifications – Smaller, more frequent meals