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These adverse embryo/fetal effects in animals coincided with pharmacological effects on maternal weight and food consumption (see Data)

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Cyanocobalamin contains roughly 20 mcg of cyanide per 1,000 mcg dose and is contraindicated in Leber's hereditary optic neuropathy, where hydroxocobalamin (dosed 1 mg every 2–3 months in UK/European practice) is the safer alternative