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Furthermore, these nanocarriers are capable of depleting GSH levels in the tumor microenvironment to augment stress on cells and induce cell death pathways, including ferroptosis, making cancer cells sensitive to treatment Fig

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Although the mechanisms underlying increased GSNO reductase activity in asthma are not clear, recent studies have demonstrated increased GSNO reductase activity in response to formaldehyde (303, 316), which is increased in the airways of asthmatics versus controls (as formate) and is associated with airway hyperreactivity and asthma severity in a concentration-dependent manner (116)