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Experimental studies suggest possible effects involving: Nitric oxide signaling Blood vessel formation (angiogenesis) Cellular communication pathways Fibroblast migration Collagen organization Tissue remodeling after injury Fibroblasts are specialized cells responsible for producing collagen and rebuilding damaged connective tissue

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KPV, the C-terminal α-MSH fragment, modulates NF-κB signaling and inflammatory-cytokine response in cell-based models