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Mechanism Adderall Mixed amphetamine salts that directly increase dopamine and norepinephrine Typically produces a faster, more noticeable “switch on” effect Direct amphetamine action Vyvanse Lisdexamfetamine prodrug converted into dextroamphetamine after ingestion Conversion occurs gradually, which can smooth the onset curve Prodrug, delayed activation Subjective Experience Adderall Faster onset with more pronounced peaks for some users Rebound “crash” symptoms are more common with short-acting dosing Sharper peaks and crashes Vyvanse Slower ramp-up with steadier focus across the day Often preferred by people who are sensitive to rebound effects Smoother, steadier profile Duration Adderall Shorter coverage window, with IR and XR formulations IR: 4–6 hours
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