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The frequency of MTHFR homozygous genotype 677CC was 89% in the vitamin B-12 group and 85% in the placebo group ( P = 0.18), and the frequency of homozygous 677TT was 0.6% in both groups ( P = 1.00)

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Thereby, there were in particular beneficial effects on the liver, including on portal hypertension, and on the intestinal tract[26-32], lung[37-39], thrombosis[21,40], venous[21] and arterial[40], and heart disturbances[41-45], free radicals formation[46-49] and free radical-induced lesions[46-50]