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One grain of thyroid (which can vary between 60mg to 65mg depending on the commercially available product and is typically approximately 65mg for bulk DTE) contains 38mcg of levothyroxine and 9mcg of liothyronine per the USP monograph for Thyroid Tablets.10 Though the above tables are not exact matches for each other, in both cases it is clear that a higher dose of synthetic levothyroxine sodium or combination levothyroxine and liothyronine sodium is needed to match the therapeutic effect of similar doses from DTE