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In a systematic review of 129359 patients from 1958 to 2021, the annual rate of decline in GFR ranged from −0.37 to −1.07 mL/min/1.73 m2/year in healthy adults without hypertension ( Under normal circumstances, renal vasodilation induces a noteworthy elevation in renal blood flow and the GFR, indicating the renal hemodynamic and functional reserve’s capacity