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The hypoxic microenvironment of RA will lead to an increase in the number of osteoclasts, increased bone resorption, and increased activity of osteolytic enzymes, thereby accelerating bone destruction (47)

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Interleukin (IL)-2 is a component of cellular immune responses and a critical immunological regulator, regulating cell development, differentiation, and proliferation and contributing to the resolution of viral or bacterial infection