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The importance of phosphorylation in DOR desensitization was challenged by the work of Qiu and colleagues who studies those processes using a DOR mutant in which all Ser/Thr residues in the C-terminus region were mutated to Ala (Qiu et al., 2007)

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This also means that some of the improvements persist after discontinuation, because the new synaptic connections Dihexa helped create remain in place